The inSIGHT study: costs and effects of routine hysteroscopy prior to a first IVF treatment cycle. A randomised controlled trial.
- Smit, J.G.
- Kasius, J.C.
- Eijkemans, M.J.
- Koks, C.A.
- Golde, R.J.T. van
- Oosterhuis, J.G.
- Nap, A.W.
- Scheffer, G.J.
- Manger, P.A.
- Hoek, A.
- Kaplan, M.
- Schoot, D.B.
- Heusden, A.M. van
- Kuchenbecker, W.K.h.
- Perquin, D.A.
- Fleischer, K.
- Kaaijk, E.M.
- Sluijmer, A.
- Friederich, J.
- Laven, J.S.E.
- Hooff, M. van
- Louwe, L.A.
- Kwee, J.
- Boomgaard, J.J.
- Koning, C.H. de
- Janssen, I.C.
- Mol, F.
- Mol, B.W.
- Torrance, H.L.
- Broekmans, F.J.
DOIAbstract
ABSTRACT: BACKGROUND: In in vitro fertilization (IVF) and intracytoplasmatic sperm injection (ICSI) treatment a large drop is present between embryo transfer and occurrence of pregnancy. The implantation rate per embryo transferred is only 30%. Studies have shown that minor intrauterine abnormalities can be found in 11-45% of infertile women with a normal transvaginal sonography or hysterosalpingography. Two randomised controlled trials have indicated that detection and treatment of these abnormalities by office hysteroscopy after two failed IVF cycles leads to a 9-13% increase in pregnancy rate. Therefore, screening of all infertile women for intracavitary pathology prior to the start of IVF/ICSI is increasingly advocated. In absence of a ...
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