Serial and panel analyses of biomarkers do not improve the prediction of bacteremia compared to one procalcitonin measurement.
- Tromp, M.
- Lansdorp, B.
- Bleeker-Rovers, C.P.
- Gunnewiek, J.M.
- Kullberg, B.J.
- Pickkers, P.
DOIAbstract
OBJECTIVES: We evaluated the value of a single biomarker, biomarker panels, biomarkers combined with clinical signs of sepsis, and serial determinations of biomarkers in the prediction of bacteremia in patients with sepsis. METHODS: Adult patients visiting the emergency department because of a suspected infection with at least two of the following symptoms: temperature >38.3 degrees C or <36 degrees C, heart rate >90/min, respiratory rate >20/min, chills, altered mental status, systolic blood pressure <90mmHg, MAP <65mmHg, and hyperglycemia in the absence of diabetes mellitus were included. Procalcitonin (PCT), interleukin-6 (IL-6), lipopolysaccharide-binding protein (LBP), C-reactive protein (CRP) were measured, and two blood cultures were...
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