Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study
- Ferrari, P.
- McKay, J.D.
- Jenab, M.
- Brennan, P.
- Canzian, F.
- Vogel, U.
- Tjonneland, A.
- Overvad, K.
- Tolstrup, J.S.
- Boutron-Ruault, M.C.
- Clavel-Chapelon, F.
- Morois, S.
- Kaaks, R.
- Boeing, H.
- Bergmann, M.
- Trichopoulou, A.
- Katsoulis, M.
- Trichopoulos, D.
- Krogh, V.
- Panico, S.
- Sacerdote, C.
- Palli, D.
- Tumino, R.
- Peeters, P.H.M.
- Gils, C.H. van
- Bueno-de-Mesquita, B.
- Vrieling, A.
- Lund, E.
- Hjartaker, A.
- Agudo, A.
- Suarez, L.R.
- Arriola, L.
- Chirlaque, M.D.
- Ardanaz, E.
- Sanchez, M.J.
- Manjer, J.
- Lindkvist, B.
- Hallmans, G.
- Palmqvist, R.
- Allen, N.
- Key, T.
- Khaw, K.T.
- Slimani, N.
- Rinaldi, S.
- Romieu, I.
- Boffetta, P.
- Romaguera, D.
- Norat, T.
- Riboli, E.
DOIAbstract
BACKGROUND/OBJECTIVES: Heavy alcohol drinking is a risk factor of colorectal cancer (CRC), but little is known on the effect of polymorphisms in the alcohol-metabolizing enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) on the alcohol-related risk of CRC in Caucasian populations. SUBJECTS/METHODS: A nested case-control study (1269 cases matched to 2107 controls by sex, age, study centre and date of blood collection) was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the impact of rs1229984 (ADH1B), rs1573496 (ADH7) and rs441 (ALDH2) polymorphisms on CRC risk. Using the wild-type variant of each polymorphism as reference category, CRC risk estimates were calculated us...
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