Size of sentinel-node metastasis and chances of non-sentinel-node involvement and survival in early stage vulvar cancer: results from GROINSS-V, a multicentre observational study.
- Oonk, M.H.
- Hemel, B.M. van
- Hollema, H.
- Hullu, J.A. de
- Ansink, A.C.
- Vergote, I.
- Verheijen, R.H.
- Maggioni, A.
- Gaarenstroom, K.N.
- Baldwin, P.J.
- Dorst, E.B. van
- Velden, J. Van der
- Hermans, R.H.
- Putten, H.W. van der
- Drouin, P.
- Runnebaum, I.B.
- Sluiter, W.J.
- Zee, A.G. van der
DOIAbstract
BACKGROUND: Currently, all patients with vulvar cancer with a positive sentinel node undergo inguinofemoral lymphadenectomy, irrespective of the size of sentinel-node metastases. Our study aimed to assess the association between size of sentinel-node metastasis and risk of metastases in non-sentinel nodes, and risk of disease-specific survival in early stage vulvar cancer. METHODS: In the GROningen INternational Study on Sentinel nodes in Vulvar cancer (GROINSS-V), sentinel-node detection was done in patients with T1-T2 (<4 cm) squamous-cell vulvar cancer, followed by inguinofemoral lymphadenectomy if metastatic disease was identified in the sentinel node, either by routine examination or pathological ultrastaging. For the present study, se...
Add to ORKG