Thickened saliva after effective management of drooling with botulinum toxin A.
- Erasmus, C.E.
- Hulst, K. van
- Hoogen, F.J.A. van den
- Limbeek, J. van
- Roeleveld, N.
- Veerman, E.C.
- Rotteveel, J.J.
- Jongerius, P.H.
DOIAbstract
AIM: The aim of this study was to evaluate the rheological properties of saliva after submandibular botulinum toxin type A (BoNT-A) injections. METHOD: We enrolled 15 children (11 males and six females; age range 3-17 y, mean age 9 y 10 mo) diagnosed with spastic (n=9) or dyskinetic (n=6) quadriplegic cerebral palsy (CP); Gross Motor Function Classification System level IV or V; and two children with intellectual disability (IQ<70) who experienced moderate to severe drooling. Salivary flow rate and drooling quotient were measured at baseline and at different times after BoNT-A injections up to 24 weeks. The mucin concentration of saliva was analysed before and after BoNT-A treatment. RESULTS: Both submandibular salivary flow rate (baseline ...
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