Timed motor tests can detect subtle motor dysfunction in early Parkinson's disease.
- Haaxma, C.A.
- Bloem, B.R.
- Overeem, S.
- Borm, G.F.
- Horstink, M.W.I.M.
DOIAbstract
Early diagnosis of Parkinson's disease (PD) is important for putative neuroprotective therapies to be initiated in the earliest stage of the disease. We investigated whether a previously validated timed motor test (TMT) battery could detect subtle motor dysfunction in early PD patients and even in clinically unaffected limbs of strictly hemiparkinsonian patients. We assessed 107 PD patients (symptom duration <or=2 years; dopa-naive) and 100 healthy, age-matched controls with eight simple TMTs based on aspects of (a) walking, (b) writing, (c) single and double-handed pegboard performance, (d) finger tapping, and (e) diadochokinesis. We evaluated the ability of individual and combined TMTs to discriminate patients from controls using ROC curv...
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