BACKGROUND: Intra-abdominal application of recombinant tissue-type plasminogen activator (rtPA) can decrease the rate of abscess formation in a rat peritonitis model. Before using rtPA clinically, its effects on healing of bowel anastomoses and laparotomy wounds should be investigated. METHODS: Peritonitis was induced in 148 male Wistar rats via intra-abdominal injection of a feces/bacteria mixture. Laparotomy, operative debridement and construction of a colo-colostomy after a limited colectomy or ileo-ileostomy after a limited ileal resection were performed after 1 hour. All animals received antibiotics (ceftriaxone plus metronidazole). In addition to untreated controls, other animals received rtPA in 1 of 3 dosing schemes, starting immedi...
Background: This study assessed the peritoneal fibrinolytic response during the first week after col...
BACKGROUND: This study assessed the peritoneal fibrinolytic response during the first week after col...
Background: This study assessed the peritoneal fibrinolytic response during the first week after col...
Contains fulltext : 81121.pdf (publisher's version ) (Closed access)BACKGROUND: In...
BACKGROUND: Optimal therapy of secondary peritonitis frequently results in the formation of residual...
Early administration of fibrinolytics after surgical treatment of peritonitis in the rat reduces abs...
Early administration of fibrinolytics after surgical treatment of peritonitis in the rat reduces abs...
BACKGROUND: Prevention of intraabdominal abscess formation constitutes an important goal in treatmen...
BACKGROUND: Intra-abdominal abscesses are sources of recurrent or ongoing abdominal sepsis. They are...
BACKGROUND: During generalized peritonitis, intraabdominal fibrin deposition is stimulated whereas f...
BACKGROUND: Recombinant tissue plasminogen activator (rtPA), administered intraperitoneally, reduces...
and M-G (p<0.01). Gentamycin did not influence the number of abscesses. BACKGROUND: Recombinant t...
Human recombinant tissue-type plasminogen activator (rtPA), administered intraperitoneally, may prom...
Background: This study assessed the peritoneal fibrinolytic response during the first week after col...
BACKGROUND: This study assessed the peritoneal fibrinolytic response during the first week after col...
Background: This study assessed the peritoneal fibrinolytic response during the first week after col...
Contains fulltext : 81121.pdf (publisher's version ) (Closed access)BACKGROUND: In...
BACKGROUND: Optimal therapy of secondary peritonitis frequently results in the formation of residual...
Early administration of fibrinolytics after surgical treatment of peritonitis in the rat reduces abs...
Early administration of fibrinolytics after surgical treatment of peritonitis in the rat reduces abs...
BACKGROUND: Prevention of intraabdominal abscess formation constitutes an important goal in treatmen...
BACKGROUND: Intra-abdominal abscesses are sources of recurrent or ongoing abdominal sepsis. They are...
BACKGROUND: During generalized peritonitis, intraabdominal fibrin deposition is stimulated whereas f...
BACKGROUND: Recombinant tissue plasminogen activator (rtPA), administered intraperitoneally, reduces...
and M-G (p<0.01). Gentamycin did not influence the number of abscesses. BACKGROUND: Recombinant t...
Human recombinant tissue-type plasminogen activator (rtPA), administered intraperitoneally, may prom...
Background: This study assessed the peritoneal fibrinolytic response during the first week after col...
BACKGROUND: This study assessed the peritoneal fibrinolytic response during the first week after col...
Background: This study assessed the peritoneal fibrinolytic response during the first week after col...