Circulating lipoproteins are a crucial component of host defense against invasive Salmonella typhimurium infection
- Netea, M.G.
- Joosten, L.A.B.
- Keuter, M.
- Wagener, F.A.D.T.G.
- Stalenhoef, A.F.H.
- Meer, J.W.M. van der
- Kullberg, B.J.
DOIAbstract
BACKGROUND: Circulating lipoproteins improve the outcome of severe Gram-negative infections through neutralizing lipopolysaccharides (LPS), thus inhibiting the release of proinflammatory cytokines. METHODS/PRINCIPAL FINDINGS: Low density lipoprotein receptor deficient (LDLR-/-) mice, with a 7-fold increase in LDL, are resistant against infection with Salmonella typhimurium (survival 100% vs 5%, p<0.001), and 100 to 1000-fold lower bacterial burden in the organs, compared with LDLR+/+ mice. Protection was not due to differences in cytokine production, phagocytosis, and killing of Salmonella organisms. The differences were caused by the excess of lipoproteins, as hyperlipoproteinemic ApoE-/- mice were also highly resistant to Salmonella infec...
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