OBJECTIVE: To assess genetic, clinical and morphological characteristics of hereditary pancreatitis, a rare type of chronic pancreatitis with an early onset of symptoms, which is, among others, caused by mutations in the PRSS1 gene. DESIGN: Observational cohort study. METHOD: The study population consisted of 496 patients (27,375 person-years) who were referred to Radboud University Nijmegen Medical Centre for molecular diagnosis of hereditary pancreatitis during period 2000 to 2007. 61 patients with a positive family history of hereditary pancreatitis were selected. Analysis for PRSS1 gene mutations was performed by complete sequence analysis of the exons. All patients received a structured questionnaire. Results : From 25 families 61 pati...
Background: acute recurrent pancreatitis is a complex multigenic disease, the diagnosis is even more...
Background and aims: Mutations in the cationic trypsinogen (protease, serine, 1 (trypsin 1); PRSS1) ...
International audienceSince the description of the PRSS1 gene encoding the cationic trypsinogen as b...
Context Hereditary pancreatitis is an autosomal dominant disease which is caused by mutations in the...
International audiencePURPOSE: Hereditary pancreatitis (HP) is the primary etiology of chronic pancr...
Pancreatitis is an inflammatory disease of the pancreas that was first identified in the 1600s. Sym...
Hereditary pancreatitis is defined as a family history of two or more relatives with pancreatitis an...
International audienceBackground: The aim was to describe genetic, clinical and morphological featur...
Background/Aims: Idiopathic pancreatitis is considered to be a multigenic and multifactorial disease...
Contains fulltext : 83242.pdf (publisher's version ) (Open Access)Chronic pancreat...
Pancreatitis is a complex acute and chronic inflammatory disease of the pancreas. Patients with chro...
Hereditary pancreatitis (HP) is a rare heterogeneous disease with partial penetrance identified by f...
Submitted to Digestive Disease Week 2020 and American College of Gastroenterology's 2021 Annual Scie...
Context Mutations in cystic fibrosis transmembrane conductance regulator (CFTR), in cationic trypsin...
Background: acute recurrent pancreatitis is a complex multigenic disease, the diagnosis is even more...
Background and aims: Mutations in the cationic trypsinogen (protease, serine, 1 (trypsin 1); PRSS1) ...
International audienceSince the description of the PRSS1 gene encoding the cationic trypsinogen as b...
Context Hereditary pancreatitis is an autosomal dominant disease which is caused by mutations in the...
International audiencePURPOSE: Hereditary pancreatitis (HP) is the primary etiology of chronic pancr...
Pancreatitis is an inflammatory disease of the pancreas that was first identified in the 1600s. Sym...
Hereditary pancreatitis is defined as a family history of two or more relatives with pancreatitis an...
International audienceBackground: The aim was to describe genetic, clinical and morphological featur...
Background/Aims: Idiopathic pancreatitis is considered to be a multigenic and multifactorial disease...
Contains fulltext : 83242.pdf (publisher's version ) (Open Access)Chronic pancreat...
Pancreatitis is a complex acute and chronic inflammatory disease of the pancreas. Patients with chro...
Hereditary pancreatitis (HP) is a rare heterogeneous disease with partial penetrance identified by f...
Submitted to Digestive Disease Week 2020 and American College of Gastroenterology's 2021 Annual Scie...
Context Mutations in cystic fibrosis transmembrane conductance regulator (CFTR), in cationic trypsin...
Background: acute recurrent pancreatitis is a complex multigenic disease, the diagnosis is even more...
Background and aims: Mutations in the cationic trypsinogen (protease, serine, 1 (trypsin 1); PRSS1) ...
International audienceSince the description of the PRSS1 gene encoding the cationic trypsinogen as b...