Pharmacokinetics of moxifloxacin in cerebrospinal fluid and plasma in patients with tuberculous meningitis.
- Alffenaar, J.W.C.
- Altena, R. van
- Bokkerink, H.J.
- Luijckx, G.J.R.
- Soolingen, D. van
- Aarnoutse, R.E.
- Werf, T.S. van der
DOIAbstract
Moxifloxacin cerebrospinal fluid (CSF) penetration was evaluated by obtaining full plasma and CSF time concentration curves for 4 patients with tuberculous meningitis. The geometric mean ratio of the areas under the curve for CSF to plasma were 0.82 (range, 0.70-0.94) at 400 mg once per day and 0.71 (0.58-0.84) at 800 mg once per day
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