We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any o...
Previously, we reported germline DNA variants associated with risk of urinary bladder cancer (UBC) i...
Previously, we reported germline DNA variants associated with risk of urinary bladder cancer (UBC) i...
We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 5...
We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,...
We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,...
Genome-wide association studies (GWAS) of urinary bladder cancer (UBC) have yielded common variants ...
Candidate gene and genome-wide association studies (GWAS) have identified 11 independent susceptibil...
Genome-wide association studies (GWAS) of urinary bladder cancer (UBC) have yielded common variants ...
Candidate gene and genome-wide association studies (GWAS) have identified 15 independent genomic reg...
Candidate gene and genome-wide association studies (GWAS) have identified 15 independent genomic reg...
Previously, we reported germline DNA variants associated with risk of urinary bladder cancer (UBC) i...
Previously, we reported germline DNA variants associated with risk of urinary bladder cancer (UBC) i...
We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 5...
We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,...
We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,...
Genome-wide association studies (GWAS) of urinary bladder cancer (UBC) have yielded common variants ...
Candidate gene and genome-wide association studies (GWAS) have identified 11 independent susceptibil...
Genome-wide association studies (GWAS) of urinary bladder cancer (UBC) have yielded common variants ...
Candidate gene and genome-wide association studies (GWAS) have identified 15 independent genomic reg...
Candidate gene and genome-wide association studies (GWAS) have identified 15 independent genomic reg...
Previously, we reported germline DNA variants associated with risk of urinary bladder cancer (UBC) i...
Previously, we reported germline DNA variants associated with risk of urinary bladder cancer (UBC) i...
We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 5...