Laparoscopic ileocolic resection versus infliximab treatment of distal ileitis in Crohn's disease: a randomized multicenter trial (LIR!C-trial).
- Eshuis, E.J.H.M.
- Bemelman, W.A.
- Bodegraven, A.A
- Sprangers, M.A.G.
- Bossuyt, P.M.
- Milligen de Wit, A.W. van
- Crolla, R.M.
- Cahen, D.H.
- Oostenbrug, L.E.
- Sosef, M.N.
- Voorburg, A.M.
- Davids, P.H.
- Woude, C.J. van der
- Lange, J. de
- Mallant, R.C.
- Boom, M.J.
- Lieverse, R.J.
- Zaag, E.S. van der
- Houben, M.H.
- Vecht, J.
- Pierik, R.E.
- Ditzhuijsen, T.J. van
- Prins, H.A.
- Marsman, W.A.
- Stockmann, H.B.
- Brink, M.
- Consten, E.C.
- Werf, S.D. van der
- Marinelli, A.W.
- Jansen, J.M.
- Gerhards, M.F.
- Bolwerk, C.J.
- Stassen, L.P.
- Spanier, B.W.
- Bilgen, E.J.
- Berkel, A.M. van
- Cense, H.A.
- Heukelem, H.A. van
- Laar, A. van t
- Slot, W.B.
- Eijsbouts, Q.A.
- Ooteghem, N.A. van
- Wagensveld, B.A. van
- Brande, J.M. van den
- Geloven, A.A. van
- Bruin, K.F.
- Maring, J.K.
- Oldenburg, B.
- Hillegersberg, R. van
- Jong, D. de
- Bleichrodt, R.P.
- Peet, D.L. van der
- Dekkers, P.E.
- Goei, T.H.
- Stokkers, P.C.
DOIAbstract
BACKGROUND: With the availability of infliximab, nowadays recurrent Crohn's disease, defined as disease refractory to immunomodulatory agents that has been treated with steroids, is generally treated with infliximab. Infliximab is an effective but expensive treatment and once started it is unclear when therapy can be discontinued. Surgical resection has been the golden standard in recurrent Crohn's disease. Laparoscopic ileocolic resection proved to be safe and is characterized by a quick symptom reduction.The objective of this study is to compare infliximab treatment with laparoscopic ileocolic resection in patients with recurrent Crohn's disease of the distal ileum with respect to quality of life and costs. METHODS/DESIGN: The study is de...
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