Induction of labour versus expectant management in women with preterm prelabour rupture of membranes between 34 and 37 weeks (the PPROMEXIL-trial).
- Ham, D.P. van der
- Nijhuis, J.G.
- Mol, B.W.
- Beek, J.J. van
- Opmeer, B.C.
- Bijlenga, D.
- Groenewout, M.
- Arabin, B.
- Bloemenkamp, K.W.
- Wijngaarden, W.J. van
- Wouters, M.G.A.J.
- Pernet, P.J.
- Porath, M.M.
- Molkenboer, J.F.
- Derks, J.B.
- Kars, M.M.
- Scheepers, H.C.J.
- Weinans, M.J.
- Woiski, M.D.
- Wildschut, H.I.J.
- Willekes, C.
DOIAbstract
BACKGROUND: Preterm prelabour rupture of the membranes (PPROM) is an important clinical problem and a dilemma for the gynaecologist. On the one hand, awaiting spontaneous labour increases the probability of infectious disease for both mother and child, whereas on the other hand induction of labour leads to preterm birth with an increase in neonatal morbidity (e.g., respiratory distress syndrome (RDS)) and a possible rise in the number of instrumental deliveries. METHODS/DESIGN: We aim to determine the effectiveness and cost-effectiveness of immediate delivery after PPROM in near term gestation compared to expectant management. Pregnant women with preterm prelabour rupture of the membranes at a gestational age from 34+0 weeks until 37+0 week...
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