Involved-field radiotherapy for patients in partial remission after chemotherapy for advanced Hodgkin's lymphoma.
- Aleman, B.M.P.
- Raemaekers, J.M.M.
- Tomisic, R.
- Baaijens, M.H.
- Bortolus, R.
- Lybeert, M.L.
- Maazen, R.W.M. van der
- Girinsky, T.
- Demeestere, G.
- Lugtenburg, P.
- Lievens, Y.
- Jong, D. de
- Pinna, A.
- Henry-Amar, M.
DOIAbstract
PURPOSE: The use of radiotherapy in patients with advanced Hodgkin's lymphoma (HL) is controversial. The purpose of this study was to describe the role of radiotherapy in patients with advanced HL who were in partial remission (PR) after chemotherapy. METHODS: In a prospective randomized trial, patients <70 years old with previously untreated Stage III-IV HL were treated with six to eight cycles of mechlorethamine, vincristine, procarbazine, prednisone/doxorubicin, bleomycine, vinblastine hybrid chemotherapy. Patients in complete remission (CR) after chemotherapy were randomized between no further treatment and involved-field radiotherapy (IF-RT). Those in PR after six cycles received IF-RT (30 Gy to originally involved nodal areas and 18-2...
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