Aminopeptidase-A (APA) is a metalloprotease that cleaves N-terminal aspartyl and glutamyl residues from peptides. Its best-known substrate is angiotensin II (Ang II), the most active compound of the renin-angiotensin system (RAS). The RAS is involved in renal development. Most components of the RAS system are expressed in the developing kidney. Thus far, APA has not been studied in detail. In the present study we have evaluated the expression of APA at the protein, mRNA, and enzyme activity (EA) level in the kidney during nephrogenesis. Furthermore, we have studied the effect of inhibiting APA EA by injection of anti-APA antibodies into 1-day-old mice. APA expression was observed from the comma stage onwards, predominantly in the developing...
The kidney and the renin-angiotensin system (RAS) are vital regulators of blood pressure and salt-wa...
Accumulating evidence suggests that angiotensin II (ANG II) plays an important role in the complex a...
Induction of albuminuria in mice: Synergistic effect of two monoclonal antibodies directed to differ...
Contains fulltext : 49894.pdf (publisher's version ) (Closed access)Aminopeptidase...
Overexpression of aminopeptidase A abolishes the growth promoting effects of angiotensin II in cultu...
Aminopeptidase A is one of the most potent enzymes within the renin-angiotensin system in terms of a...
Aminopeptidase A activity and angiotensin III effects on [Ca2+]i along the rat nephron.BackgroundThi...
Item does not contain fulltextIt has been shown that injection of combinations of anti-aminopeptidas...
Cell surface aminopeptidase A and N activities in human glomerular epithelial cells. Cell surface am...
Aminopeptidase A: A nephritogenic target antigen of nephrotoxic serum.BackgroundWe investigated pote...
Aminopeptidase A(APA) is an important Renin-Angiotensin-System(RAS) enzyme which is predominantly ex...
Contains fulltext : 144233.pdf (Publisher’s version ) (Closed access)Administratio...
AbstractMembrane-bound peptidases are critical regulators of peptide hormones. We therefore characte...
Glomerular angiotensinase A in the rat: Increase of enzyme activity following renal ablation. Angiot...
It is well documented that angiotensin (Ang) II contributes to kidney disease progression. The prote...
The kidney and the renin-angiotensin system (RAS) are vital regulators of blood pressure and salt-wa...
Accumulating evidence suggests that angiotensin II (ANG II) plays an important role in the complex a...
Induction of albuminuria in mice: Synergistic effect of two monoclonal antibodies directed to differ...
Contains fulltext : 49894.pdf (publisher's version ) (Closed access)Aminopeptidase...
Overexpression of aminopeptidase A abolishes the growth promoting effects of angiotensin II in cultu...
Aminopeptidase A is one of the most potent enzymes within the renin-angiotensin system in terms of a...
Aminopeptidase A activity and angiotensin III effects on [Ca2+]i along the rat nephron.BackgroundThi...
Item does not contain fulltextIt has been shown that injection of combinations of anti-aminopeptidas...
Cell surface aminopeptidase A and N activities in human glomerular epithelial cells. Cell surface am...
Aminopeptidase A: A nephritogenic target antigen of nephrotoxic serum.BackgroundWe investigated pote...
Aminopeptidase A(APA) is an important Renin-Angiotensin-System(RAS) enzyme which is predominantly ex...
Contains fulltext : 144233.pdf (Publisher’s version ) (Closed access)Administratio...
AbstractMembrane-bound peptidases are critical regulators of peptide hormones. We therefore characte...
Glomerular angiotensinase A in the rat: Increase of enzyme activity following renal ablation. Angiot...
It is well documented that angiotensin (Ang) II contributes to kidney disease progression. The prote...
The kidney and the renin-angiotensin system (RAS) are vital regulators of blood pressure and salt-wa...
Accumulating evidence suggests that angiotensin II (ANG II) plays an important role in the complex a...
Induction of albuminuria in mice: Synergistic effect of two monoclonal antibodies directed to differ...