Pharmacokinetics of once-daily lopinavir/ritonavir and the influence of dose modifications.
- Porte, C.J.L. la
- Schippers, E.F.
- Ende, M.E. van der
- Koopmans †, P.P.
- Blok, W.L.
- Kauffmann, R.H.
- Kroon, F.P.
- Burger, D.M.
Publication date
January 2005
DOI ISSN
0269-9370 Citation count (estimate)
6Abstract
We studied the pharmacokinetics of lopinavir/ritonavir dosed at 800/200 mg a day in 20 HIV-1-infected patients, and evaluated the effect of dose modifications in the case of trough concentration (Ctrough) levels less than 1.0 mg/l. Ctrough levels after the daily administration of lopinavir/ritonavir were lower than with twice daily administration. Dose modifications in four patients with Ctrough levels less than 1.0 mg/l succeeded in only one patient. Therapeutic drug monitoring can identify patients with lower-than-expected lopinavir exposure in a larger study
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