Deciphering the evolution and metabolism of an anammox bacterium from a community genome.
- Strous, M.
- Pelletier, E.
- Mangenot, S.
- Rattei, T.
- Lehner, A.
- Taylor, M.W.
- Horn, M.
- Daims, H.
- Bartol-Mavel, D.
- Wincker, P.
- Barbe, V.
- Fonknechten, N.
- Vallenet, D.
- Segurens, B.
- Schenowitz-Truong, C.
- Medigue, C.
- Collingro, A.
- Snel, B.
- Dutilh, B.E.
- Camp, H.J.M. op den
- Drift, C. van der
- Cirpus, I.E.Y.
- Pas-Schoonen, K.T. van de
- Harhangi, R.H.
- Niftrik, L.A.M.P. van
- Schmid, M.
- Keltjens, J.T.M.
- Vossenberg, J.L.C.M. van de
- Kartal, B.
- Meier, H.
- Frishman, D.
- Huynen, M.A.
- Mewes, H.W.
- Weissenbach, J.
- Jetten, M.S.M.
- Wagner, M.
- Paslier, D. Le
DOIAbstract
Anaerobic ammonium oxidation (anammox) has become a main focus in oceanography and wastewater treatment. It is also the nitrogen cycle's major remaining biochemical enigma. Among its features, the occurrence of hydrazine as a free intermediate of catabolism, the biosynthesis of ladderane lipids and the role of cytoplasm differentiation are unique in biology. Here we use environmental genomics--the reconstruction of genomic data directly from the environment--to assemble the genome of the uncultured anammox bacterium Kuenenia stuttgartiensis from a complex bioreactor community. The genome data illuminate the evolutionary history of the Planctomycetes and allow us to expose the genetic blueprint of the organism's special properties. Most sign...
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