Fusidic acid resistance in Staphylococcus aureus nasal carriage strains in nine European countries.
- Heijer, C.D.J. den
- Bijnen, E.M.E. van
- Paget, W.J.
- Stobberingh, E.E.
DOIAbstract
Aim: To evaluate fusidic acid resistance pheno- and geno-typically in nasal carriage Staphylococcus aureus isolated from general practice patients in nine European countries. Materials & methods: Phenotypic fusidic acid resistance was determined by disc diffusion and MIC values, and genotypically by a PCR detecting fusA–E genes. The main analysis was performed on methicillin-susceptible S. aureus strains, because methicillin-resistant S. aureus isolates were scarce. Results: Overall S. aureus fusidic acid resistance was low (<10%). fusC was the predominant mechanism of resistance and associations were found between resistance genes and specific spa types. Conclusion: S. aureus strains showed low resistance to fusidic acid, making this antib...
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