Su vaistų vartojimu susijusių problemų įvertinimas pacientams, sergantiems arterine hipertenzija

The aim of the thesis. To determine the type of drug – related problems and their most common reasons for patients who suffer from arterial hypertension. Objectives of the research. 1) To determine the drug - related problems in the investigative patients’ groups. 2) To analyze the identified problems and compare with the results from other studies. 3) To identify risk factors which affect DRP in hypertensive patients. 4) To make recommendations for the patient to prevent possible problems. Methodology. This study was questionnaire – based which was conducted between July to August 2016 in Kaliningrad, Russia and from January to February 2017 in Kaunas, Lithuania. A convenient sampling method was used and a total of 100 hypertensive patients were included in the study. DRPs were identified based on strand classification system and trustable literature. Data were analyzed using Excel and SPSS software program. Descriptive statistics were generated in the form of numbers and percentage. To summarize the quantitative variables, mean and standard deviation (SD) were calculated, and for the qualitative variables, frequencies and percentages were used. Results. The frequency of DRPs was identified 92% vs. 100% in the investigative group in Kaunas and Kaliningrad, respectively. One hundred and fourteen DRPs were identified in each city, an average of 2.3 DRP for each participant. Identified DRPs were unnecessary drug therapy (7.9% vs. 3.5%), needs an additional drug therapy (14.1% vs. 31.6%), ineffective therapy (25.4% vs. 15.8%), adverse drug reaction (27.2% vs. 17.5%), and non – adherence (25.4% vs. 31.6%) in Kaliningrad and Kaunas, respectively. Prevalence of risk factors for BP in the evaluated population was minimal: 82% vs. 72% respondents don’t smoke, 62% vs. 88% don’t consume alcohol; however, only 32% vs. 20% are doing sports and 90% vs. 84% has comorbid diseases in Kaliningrad and Kaunas, consequently. Conclusion. A number of drugs and number of comorbidities significantly affect drug – related problems. The study showed that almost all the patients in the study have drug therapy problems. For that reason, patients with multiple diagnosis and patients using multiple drugs should be closely monitored for drug – related problems, to avoid clinically significant harmful consequences. The monitoring of medicines use is an effective way to decrease the number of DRPs and to ensure safety and efficacy