MoModeling, rheological and biopharmaceutical evaluation of semisolid formulations with natural substances

[...]. The aim of this work was to model stable, evidenced by research semisolid formulations with natural components and to evaluate its rheological and biopharmaceutical properties. The objectives of work were: 1. To model semisolid bases using natural substances and evaluate its rheological characteristics and stability. 2. To evaluate possibilities to use honey in modelling of semisolid formulations. 3. To evaluate antiradical and antimicrobial activity and penetration into human skin possibilities of components of hawthorn (chlorogenic acid, vitexin-2"-O-rhamnoside, hyperoside, isoquercitrin) and lemon balm (rosmarinic acid) extracts with in vitro and ex vivo methods. 4. To investigate selected herbal extracts influence to the rheological properties of semisolid formulations. 5. To determine release and penetration kinetics of the main phenolic components of selected herbal extracts from the semisolid formulations with the biopharmaceutical methods in vitro. [...]