Allergic and immunological aspects of therapy with cefotaxime and other cephalosporins

Immunogenicity and allergenicity studies in rodents show that cefotaxime and cefur-oxime are less immunogenic than benzylpenicillin or the semisynthetic penicillins. Cross-reactions of these antibiotics with benzylpenicilloyl-specific animal and human IgE antibodies appear minimal. Some cross-reactivity at the level of cell-mediated allergic reactions may, however, be expecte