Add to ORKGA recent genome-wide association study (GWAS) involving patients with hemophilia A who were exposed to but uninfected with human immunodeficiency virus type 1 (HIV-1) did not reveal genetic variants associated with resistance to HIV-1 infection, beyond homozygosity for CCR5-Δ32. Since variation in HLA class I and KIR genes is not well interrogated by standard GWAS techniques, we tested whether these 2 loci were involved in protection from HIV-1 infection in the same hemophilia cohort, using controls from the general population. Our data indicate that HLA class I alleles, presence or absence of KIR genes, and functionally relevant combinations of the HLA/KIR genotypes are not involved in resistance to parenterally transmitted HIV-1 infectio
Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infe...
Genetic and functional studies have demonstrated that KIR gene polymorphism, including different hap...
HLA-B*51 alleles are reported to be associated with slow disease progression to AIDS, but the mechan...
A recent genome-wide association study (GWAS) involving patients with hemophilia A who were exposed ...
A recent genome-wide association study (GWAS) involving patients with hemophilia A who were exposed ...
Multiple epidemiological studies have demonstrated associations between the human leukocyte antigen ...
Human genetic variation contributes to differences in susceptibility to HIV-1 infection. To search f...
Human genetic variation contributes to differences in susceptibility to HIV-1 infection. To search f...
In West Africa, the Acquired Immunodeficiency Syndrome (AIDS) is caused by both types of Human Immun...
BACKGROUND: In HIV-infected individuals, mechanisms underlying unsatisfactory immune recovery during...
The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation,...
Objective: The objective of this study is to identify human leukocyte antigen (HLA) class I and kil...
NK cell receptors and HLA molecules are intimately involved in the immune response against viral inf...
Background: Killer-cell Immunoglobulin-like Receptors (KIR) interact with Human Leukocyte Antigen(HL...
Several studies demonstrated a relevant role of polymorphisms located within the HLA-B and -C loci a...
Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infe...
Genetic and functional studies have demonstrated that KIR gene polymorphism, including different hap...
HLA-B*51 alleles are reported to be associated with slow disease progression to AIDS, but the mechan...
A recent genome-wide association study (GWAS) involving patients with hemophilia A who were exposed ...
A recent genome-wide association study (GWAS) involving patients with hemophilia A who were exposed ...
Multiple epidemiological studies have demonstrated associations between the human leukocyte antigen ...
Human genetic variation contributes to differences in susceptibility to HIV-1 infection. To search f...
Human genetic variation contributes to differences in susceptibility to HIV-1 infection. To search f...
In West Africa, the Acquired Immunodeficiency Syndrome (AIDS) is caused by both types of Human Immun...
BACKGROUND: In HIV-infected individuals, mechanisms underlying unsatisfactory immune recovery during...
The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation,...
Objective: The objective of this study is to identify human leukocyte antigen (HLA) class I and kil...
NK cell receptors and HLA molecules are intimately involved in the immune response against viral inf...
Background: Killer-cell Immunoglobulin-like Receptors (KIR) interact with Human Leukocyte Antigen(HL...
Several studies demonstrated a relevant role of polymorphisms located within the HLA-B and -C loci a...
Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infe...
Genetic and functional studies have demonstrated that KIR gene polymorphism, including different hap...
HLA-B*51 alleles are reported to be associated with slow disease progression to AIDS, but the mechan...