Add to ORKGIn experimental rabbit meningitis, cefepime given at a dose of 100 mg/kg was associated with concentrations in the cerebrospinal fluid of between 5.3 and 10 mg/L and a bactericidal activity of −0.61 ± 0.24 δlog10 cfu/mL•h, similar to the standard regimen of ceftriaxone combined with vancomycin (−0.58 ± 0.14 δlog10 cfu/mL•h) in the treatment of meningitis due to a penicillin- and quinolone-resistant pneumococcal mutant strain (MIC 4 mg/L). Compared with the penicillin-resistant parental strain, the penicillin- and quinolone-resistant mutant was killed more slowly by cefepime and ceftriaxone in time-killing assays in vitro over 8
The continuous increase of resistant pathogens causing meningitis has limited the efficacy of standa...
Grepafloxacin, a new fluoroquinolone, produced bactericidal activity comparable to that of vancomyci...
The fluoroquinolone trovafloxacin was bactericidal (0.47 6 0.23 Dlog10 CFU/ml z h after 10 mg/kg of ...
In experimental rabbit meningitis, cefepime given at a dose of 100 mg/kg was associated with concent...
Cefepime, a broad-spectrum, fourth-generation cephalosporin, showed excellent CSF penetration with l...
Gatifloxacin penetrated well into cerebrospinal fluid (CSF) (49 ± 11%), measured by comparison of AU...
BMS 284756 penetrated well into inflamed meninges (44% +/- 11%) and produced good bactericidal activ...
Using a rabbit model of pneumococcal meningitis, we compared the pharmacokinetics and bactericidal a...
OBJECTIVES: To test the efficacy of EDP-420, a new ketolide, in experimental pneumococcal meningitis...
In experimental rabbit meningitis, gemifloxacin penetrated inflamed meninges well (22 to 33%) and pr...
Objectives: To test the efficacy of EDP-420, a new ketolide, in experimental pneumococcal meningitis...
WOS: 000232211600013PubMed ID: 16099624This study was planned to compare the efficacy of ceftriaxone...
PubMed ID: 16099624This study was planned to compare the efficacy of ceftriaxone + vancomycin with c...
Abstract This study was planned to compare the efficacy of ceftriaxone + vancomycin with ceftriaxone...
Four new cephalosporins, cefotaxime, cefpimizole (U 63196E), BMY 28142, and HR 810 were evaluated in...
The continuous increase of resistant pathogens causing meningitis has limited the efficacy of standa...
Grepafloxacin, a new fluoroquinolone, produced bactericidal activity comparable to that of vancomyci...
The fluoroquinolone trovafloxacin was bactericidal (0.47 6 0.23 Dlog10 CFU/ml z h after 10 mg/kg of ...
In experimental rabbit meningitis, cefepime given at a dose of 100 mg/kg was associated with concent...
Cefepime, a broad-spectrum, fourth-generation cephalosporin, showed excellent CSF penetration with l...
Gatifloxacin penetrated well into cerebrospinal fluid (CSF) (49 ± 11%), measured by comparison of AU...
BMS 284756 penetrated well into inflamed meninges (44% +/- 11%) and produced good bactericidal activ...
Using a rabbit model of pneumococcal meningitis, we compared the pharmacokinetics and bactericidal a...
OBJECTIVES: To test the efficacy of EDP-420, a new ketolide, in experimental pneumococcal meningitis...
In experimental rabbit meningitis, gemifloxacin penetrated inflamed meninges well (22 to 33%) and pr...
Objectives: To test the efficacy of EDP-420, a new ketolide, in experimental pneumococcal meningitis...
WOS: 000232211600013PubMed ID: 16099624This study was planned to compare the efficacy of ceftriaxone...
PubMed ID: 16099624This study was planned to compare the efficacy of ceftriaxone + vancomycin with c...
Abstract This study was planned to compare the efficacy of ceftriaxone + vancomycin with ceftriaxone...
Four new cephalosporins, cefotaxime, cefpimizole (U 63196E), BMY 28142, and HR 810 were evaluated in...
The continuous increase of resistant pathogens causing meningitis has limited the efficacy of standa...
Grepafloxacin, a new fluoroquinolone, produced bactericidal activity comparable to that of vancomyci...
The fluoroquinolone trovafloxacin was bactericidal (0.47 6 0.23 Dlog10 CFU/ml z h after 10 mg/kg of ...