A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
- Greider, C. W.
- Blackburn, E. H.
Publication date
January 1989
DOI Publisher
Springer Science and Business Media LLC ISSN
0028-0836 Citation count (estimate)
1148Abstract
The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA component of this ribonucleoprotein enzyme has now been cloned and found to contain the sequence CAACCCCAA, which seems to be the template for the synthesis of TTGGGG repeats