Cancer is an evolving, dynamic, evasive and heterogeneous disease, characterized by high morbidity and mortality. It is widely acknowledged that the tumor microenvironment plays a fundamental role in cancer development and progression. Despite this, most in vitro cancer models are simple, two-dimensional monocultures of immortalized tumor cell lines. There is an immediate need to develop three-dimensional, multicellular biomimetic in vitro constructs that can model specific stages of tumorigenesis to aid cancer research and drug discovery. This chapter aims to review the latest advances in three-dimensional bioengineered cancer modeling, with particular focus on models that retain the biological and physical characteristics of the in vivo t...
Basic in vitro systems can be used to model and assess complex diseases, such as cancer. Recent adva...
Human cancer cell lines are an integral part of drug discovery practices. However, modeling the comp...
Tumor microenvironment is a highly complex system consisting of non-cancerous cells, soluble factors...
Cancers are complex and heterogeneous pathological “organs” in a dynamic interplay with their host. ...
Cancers are complex and heterogeneous pathological "organs" in a dynamic interplay with their host. ...
Cancer occurs when cells acquire genomic instability and inflammation, produce abnormal levels of ep...
Tissue engineering aims to gain mechanistic insights into human diseases and to develop new treatmen...
Three-dimensional (3D) cell cultures have recently garnered great attention because they promote lev...
Anticancer drug discovery has long been hampered by the poor predictivity of the preclinical models....
Limitations associated with the study of cancer biology in vitro, including a lack of extracellular ...
Limitations associated with the study of cancer biology in vitro, including a lack of extracellular ...
Although advances have been made in cancer therapy, cancer remains the second leading cause of death...
Three-dimensional (3D) tissue culture models have an invaluable role in tumour biology today providi...
Prostate cancer is the most commonly diagnosed malignancy in men and advanced disease is incurable. ...
The lack of traditional cancer treatments has resulted in an increased need for new clinical techniq...
Basic in vitro systems can be used to model and assess complex diseases, such as cancer. Recent adva...
Human cancer cell lines are an integral part of drug discovery practices. However, modeling the comp...
Tumor microenvironment is a highly complex system consisting of non-cancerous cells, soluble factors...
Cancers are complex and heterogeneous pathological “organs” in a dynamic interplay with their host. ...
Cancers are complex and heterogeneous pathological "organs" in a dynamic interplay with their host. ...
Cancer occurs when cells acquire genomic instability and inflammation, produce abnormal levels of ep...
Tissue engineering aims to gain mechanistic insights into human diseases and to develop new treatmen...
Three-dimensional (3D) cell cultures have recently garnered great attention because they promote lev...
Anticancer drug discovery has long been hampered by the poor predictivity of the preclinical models....
Limitations associated with the study of cancer biology in vitro, including a lack of extracellular ...
Limitations associated with the study of cancer biology in vitro, including a lack of extracellular ...
Although advances have been made in cancer therapy, cancer remains the second leading cause of death...
Three-dimensional (3D) tissue culture models have an invaluable role in tumour biology today providi...
Prostate cancer is the most commonly diagnosed malignancy in men and advanced disease is incurable. ...
The lack of traditional cancer treatments has resulted in an increased need for new clinical techniq...
Basic in vitro systems can be used to model and assess complex diseases, such as cancer. Recent adva...
Human cancer cell lines are an integral part of drug discovery practices. However, modeling the comp...
Tumor microenvironment is a highly complex system consisting of non-cancerous cells, soluble factors...