RHEUMATIC DISEASES AND MALIGNANSY – WHERE IS THE ASSOCIATION?

Bolesnici s upalnim autoimunim reumatskim bolestima imaju povećan rizik od obolijevanja od malignih bolesti, uključujući limfoproliferativne sindrome i leukemije, osobito oni s reumatoidnim artritisom, sistemskim lupusom, Sjögrenovim sindromom, dermatomiozitisom i sistemskom sklerozom. Povećana učestalost malignih bolesti dovodi se u vezu s autoimunošću, kroničnom upalnom aktivnošću, ali i imunomodulatornom i imunosupresivnom terapijom. Reumatske tegobe mogu biti dio slike paraneoplastičkog sindroma što dodatno utječe na diferencijalnu dijagnozu, praćenje tijeka bolesti i izbor terapije uz procjenu individualnog rizika i utjecaja okolišnih čimbenika.Patients with inflammatory autoimmune rheumatic diseases, especially those with rheumatoid arthritis, systemic lupus erythematosus, Sjögren’s syndrome, dermatomyositis, and systemic sclerosis, are at increased risk of malignancies, including leukemia and lymphoproliferative syndromes. An increased incidence of malignant disease is associated with autoimmunity, chronic inflammatory activity, as well as immunomodulatory and immunosuppressive therapy. Rheumatic manifestations can be part of paraneoplastic syndrome, which may further affect the differential diagnosis, disease monitoring, or treatment strategies along with the assessment of individual risks and the impact of environmental factors