Toxic methemoglobinemia in the manufacture of aniline dyes

Prikazana je toksična methernoglobinemija u proizvodnji anilinskih boja u jednom poduzeću kemijske industrije u Zagrebu. Analiza tehnološkog procesa pokazala je, da je za konverziju hemoglobina u methemoglobin odgovorna vjerojatno boja: naphtol-blau schwarz 1OB s obzirom da ta boja sadrži anilin i p-nitroanIin, t. j. supstancije s izraženim methemoglobinskim efektom. Prodiskutirani su ostali simptomi otrovanja i laboratorijski nalazi i uspoređeni su s Iiteraturnim podacima o intoksikaciji amino i nitro derivatima benzena.Two cases of toxic methemoglohinemia in a chemical plant in Zagreb are reported. The analysis of the technological process has shown that the conversion from hemoglobin into methemoglobin was likely to be due to naphtol-blau schwarz 10B, a dye containing aniline and p-nitroaniline, i. e. the substances with a pronounced methemoglobin-forming effect. The symptoms of poisoning and laboratory findings are discussed and compared with literature data on intoxication due to amino and nitro benzene derivatives