Study of dermal toxicity of organophosphorus compounds. I. Parathion toxicity in relation to the skin surface and the technique of application

Istražen je učinak pripreme površine kože štakora kao i pokrivanje kontaminirane površine na perkutanu otrovnost parationa. Uklanjanje masnog sloja s ošišane kože leda 24 sata prije aplikacije otrova nije utjecalo na otrovnost parationa. Pokrivanje kontaminiranog mjesta politenskim listićem smanjilo je otrovnost parationa za oko 2 puta, a pokrivanje kontaminiranog mjesta leukoplastom za oko 3,5 puta. Pokusi u kojima je mogućnost ingestije otrova kod nepokrivenih štakora bila djelomično ili potpuno spriječena pokazali su da veće LD50 vrijednosti dobivene pokrivanjem kontaminiranog mjesta nisu rezultat spriječenog unošenja otrova peroralnim putem, već su posljedica smanjenog prodiranja parationa kroz kožu. To se može tumačiti adhezijom otrova na politenski listić, odnosno leukoplast, kojima je kontaminirano mjesto bilo pokriveno.The effect of the preparation of the rat\u27s skin surface and the covering of the contaminated area on dermal Parathion toxicity was investigated. The removal of the fatty layer from the clipped back skin area 24 hours prior to the application of the poison had no effect on Parathion toxicity. Parathion toxicity was reduced to about twice when the contaminated area was covered with a polythene sheet, and to about three and a half times when cevered with a leukoplast. The experiments, in which the possibility of ingestion of the poison in uncovered rats was partly or completely avoided, have shown that higher LD50 values obtained by covering the contaminated area were not due to the prevented introduction of the poison by ingestion but to a reduced penetration of Parathion through the skin. This may be explained by the adhesion of the poison to the polythene sheet or leukoplast by which the contaminated area was covered