Uji Efek Analgesik Ekstrak Etanol Buah Mengkudu (Morinda Citrifolia L.) Pada Mencit (Mus Musculus)

: Population Indonesia has long been known and used medicinal plants in effort to cope with health problems. Noni plant (Morinda citrifolia L.) is included in the medicinal plants that have been used for traditional medicine in Indonesia, one of them as analgesic. According Younos et al. (1990), noni extract has analgesic effect. Xeronine compound of the noni fruit is suspected to have an analgesic effect. The purpose of this study whether there analgesic effect of ethanol extract of noni fruit (Morinda citrifolia L.) in mice (Mus musculus). This study is an experimental study using heat stimuli such as temperature of 55˚C. This study used laboratory animals such as female mice which were divided into five groups, each consisting of three mices. Group I as negative control was given 0.4 ml of distilled water, group II as positive control was given paracetamol 1000mg/50kgBB, group III as treatment group was given ethanol extract of noni fruit 200mg/kgBB, group IV as treatment group was given ethanol extract of noni fruit 400mg/kgBB and group V as treatment group was given ethanol extract of noni fruit 800mg/kgBB. An observation was carried out for one minute with the expected response being jumping and licking its feet as a reaction to reduce the pain. From the experimental results by providing heat stimuli such as temperature of 55˚C showed that the response of mice decreased in all thre treatment groups compared with the positive control which was given paracetamol.The ethanol extract of noni fruit(Morinda citrifolia L.) has an analgesic effect on mice (Mus musculus)