Gambaran Histopatologik Hati Tikus Wistar Yang Diberikan Air Rebusan Daun Sendok (Plantago Major) Pasca Induksi Karbon Tetraklorida (Ccl4)

: The common plantain (plantago major) contains the compound aucubin which has been demonstrated to have theraupetic effects in improving liver cells as hepatoprotector. The objective of this study was to reveal the histopathological features of the liver of wistar rats administered with the hot water extract of Plantago major after induction with carbon tetrachloride (CCl4). This study was a laboratory experimental research employing 14 wistar rats; two rats were used as the negative control fed with regular pellets for 5 days, two rats as the positif control fed with pellets containing CCl4 of 0.05 cc for five days, five rats as treatment group receiving pellets containing CCl4 of 0.05 cc for five days and were fed with regular pellets afterwards, and five rats received pellets containing CCl4 of 0.05 cc for five days and were administered with the hot water extract of Plantago major 0f 1.6 cc. Results showed that rats in the negative control exhibited normal macroscopic and microscopic features. In the positive control group, the microscopic features demonstrated liver cells with steatosis. Meanwhile, the rats administered with the water extract of Plantago major showed liver cells which had regenerated. It is concluded that the administration of the water extract of Plantago major can improve the liver cells by diffuse regeneration