Obat Dan Suplemen Untuk Osteoarthritis

Osteoarthritis (OA) is one cause of disability activities in geriatrics. The goals of OA therapy are to control symptoms, minimize disability and improve the quality of life. Management of OA include non-pharmacological therapy, pharmacological therapy, and surgery. Pharmacological therapy is further classified into symptomatic therapy and disease modifying therapy. Acetaminophen, the first-line symptomatic therapy, is used by consider the risk of gastrointestinal and cardiovascular toxicity, especially in geriatric. Intra-articular injection of glucocorticoid or hyalurodonic acids provided short-term benefit effects. Currently research is still conducted on disease modifier drugs, such as tetracycline, glycosaminoglycans polysulfuric acid, pentosan polysulphate, diacerein, glucosamine and others. Researchs of new drug targets such as Interleucine-1R receptor antagonist (IL-1Ra), inhibitors of mitogen-activated protein (MAP) kinases, NF-kappaB inhibitor, are also continuously conducted. In addition, gene therapy, stem cell and chondrocytes transplantation also being developed. Various supplements have been widely used for the treatment of OA, such as glucosamine, chondroitin sulfate, ginger extract, avocado and soy, herbs cat's claw, as well as shark cartilage. Glucosamine and chondroitin sulfate are nutraceuticals that provided the most significant effect in the treatment of OA. Key words: osteoarthritis, pharmacological therapy, supplements drug