Multi-modal fMRI study on brain structure and function in different factors induced rat chronic obstructive pulmonary disease

慢性阻塞性肺病（chronicobstructivepulmonarydisease，COPD）脑结构和功能的异常在近些年受到了越来越多的研究关注。先前的神经影像学研究已经发现COPD伴随着白质完整性的损害和灰质的丢失，以及功能连接网络的异常。但是吸烟和非吸烟(如慢性肺部炎症)诱导的COPD病人脑部形态学和功能的异同，以及吸烟和感染因素的综合诱导是否加重了脑损害尚不清楚。致病因素和COPD病人脑部异常的特征性对应关系仍待进一步的探究。 本实验的目的是使用COPD的两个最主要风险因素吸烟和肺部炎症进行COPD大鼠模型的构建，探究在不同诱导条件下（吸烟和呼吸道炎症）的COPD对脑部灰质体积以及静...Growing research concern has been devoted to the central abnormalities in chronic obstructive pulmonary disease (COPD) recently. Previous neuroimaging studies have demonstrated that COPD accompanied with white matter microstructure damage, grey matter (GM) loss, and abnormal functional connectivity. However, differences in brain morphology and function between smoking and non-smoking (e.g., chroni...学位：理学硕士院系专业：医学院_生理学学号：2452012115314