The isolation and identification of anticancer compounds targeting nuclear receptor from leaves of Magnolia biloba and seeds of Camellia oleifera

靶点药物研究已成为现代新药研究与开发的潮流，而核受体被发现与多种重大疾病特别是癌症的发生发展关系密切，并已被确认是一种理想的药物靶标。孤儿核受体TR3/Bcl-2凋亡途径及tRXRα/p85信号转导通道是本研究团队近年来发现的两条独特的癌细胞凋亡调控通路。寻找靶向并调控这些核受体信号通路的小分子药物将能特异有效的抑制肿瘤细胞的生长，十分具有开发成新型靶向抗癌药物的潜力。我们前期科研成果的基础上，建立生物活性筛选模型，对两种有靶向核受体发挥抗癌作用潜力的厚朴叶及油茶籽的醇提物进行的更细致的化学成分分离与化学结构鉴定。研究共从厚朴叶获得化合物11个，通过核磁及质谱分析鉴定为：厚朴酚(1)、和厚朴酚...The study of the targeted drugs has become the new trend of the new drug development and study, and the nuclear receptor is reported of a near relationship of many diseases. It has been ensured of an ideal drug target which is related to many diseases. The apoptosis pathway of orphan nuclear receptor TR3/Bcl-2 and the tRXRα/p85 signaling transduction pathway are the unique regulatory pathways that...学位：医学硕士院系专业：药学院_药物化学学号：3232012115309