The Role of SNX8 in Alzheimer’s Disease

阿尔茨海默病（Alzheimer’sdisease，AD）一个重要的病理学特征是在神经细胞外形成主要由β淀粉样蛋白（βamyloid，Aβ）组成的淀粉样斑（amyloidplaques）。大脑内具有神经毒性的Aβ的累积在AD的发病过程中处于中心地位。β淀粉样蛋白前体蛋白（βamyloidprecursorprotein，APP）依次经过β分泌酶和γ分泌酶切割后可以产生Aβ和APP的胞内结构域（APPintracellulardomain，AICD）。APP还可以被α分泌酶切割产生具有神经保护作用的sAPPα。许多研究发现α分泌酶主要在细胞膜上对APP进行切割，而β分泌酶主要在内体（Endsom...One of the neuropathologic hallmarks of Alzheimer’s disease (AD) is the presence of senile plaques which consist of β-amyloid peptide (Aβ) in the brain. Accumulation of the neurotoxic Aβ in the brain is central to the pathogenesis of AD. Aβ is derived from β-amyloid precursor protein (APP) through sequential cleavages by the β-secretase and the γ-secretase. In addition to amyloidogenic processing,...学位：理学博士院系专业：生物医学研究院_化学生物学学号：3052010015394