The Regulating Function of Nucleoporin Sec13 in Central Nervous System and Pheriphral Nervous System Myelination

核孔复合体是细胞核核孔上由核孔蛋白组成的复合体，为细胞质和细胞核之间物质运输提供通道。运输的物质包括小分子和大分子蛋白、mRNA等，而准确无误的核孔复合体组装对维持细胞生理功能必不可少。脊椎动物核孔复合体中包含Nup107-160复合体，Sec13是其组成成分。同时，Sec13还参与COPII囊泡的构成。近年来，研究发现Sec13在视网膜发育和消化系统发育中具有重要作用，另外，同为Nup107-160复合体组成成分的Nup133被证实在小鼠神经干细胞分化中具有调控作用。那么Sec13在神经系统发育尤其是髓鞘发生中有无作用？这引起了我们的兴趣。 首先，我们的实验结果显示，Sec13是一个泛组织...Nuclear pore complexes(NPCs) are large complex formed by nucleoporins that anchor at the nuclear pore. They serve as channels connecting the nucleus and cytoplasm.These molecular exchanges include the movement of small molecules and transportation of large proteins as well as RNA.Precise assembly of nuclear pore complexes is the Key for the maintainance of normal cellular physiological functions.T...学位：理学硕士院系专业：生命科学学院_生物化学与分子生物学学号：2162013115257