IMPDH2 promotes migration and invasion in cancer cells by sumoylation

IMPDH2是GTP从头合成代谢的关键酶，在多种肿瘤组织和分生活跃的组织中高表达。IMPDH2可以通过SUMO化修饰调节自身酶活。在癌细胞中，IMPDH2的SUMO化促进酶活并通过调节细胞内GTP的含量发挥生物学功能。细胞内含有众多的小GTP蛋白(smallGTPase)，这些蛋白通过与GTP结合从而处于活化状态。活化的小GTP蛋白可以与其下游效应蛋白结合，启动或者传递信号以发挥生物学功能。其中，Rho蛋白家族的主要成员RhoA、cdc42等参与了肌动蛋白的聚合以及与之相关的生物学进程，比如黏附，迁移与侵袭。 本文通过一系列实验发现，SUMO化的IMPDH2可以通过提高自身酶活，在肿瘤细胞内...IMPDH2 is the rate-limiting enzyme of GTP de novo synthesis,which is overexpressed in many kinds of tumor tissues and normal tissues with high proliferation. The enzyme activity of IMPDH2 could be regulated by sumoylation. sumoylated IMPDH2 can regulate the GTP level in cancer cells and exert corresponding biological functions. Small GTPase could be activated through binding with GTP. The activate...学位：理学硕士院系专业：生命科学学院_细胞生物学学号：2162013115252