Enhancement of hypothalamic STAT3 acetylation by nuclear receptor Nur77 dictates leptin sensitivity

孤儿核受体Nur77（也称为TR3）是核受体家族NR4A的一员，在脂肪、肝脏和骨骼肌组织的代谢调控中发挥重要功能，因此被认为是一种新型的治疗代谢性疾病的药物靶点。本文研究中我们发现，在正常生理条件下，随着年龄的增长，Nur77基因敲除的小鼠体重明显高于野生型小鼠。摄食的增多和能量消耗的减少是Nur77基因敲除小鼠体重上升的直接原因。棕色脂肪组织耗能产热功能的衰退也促使了脂肪的积累。原位杂交和实时荧光定量PCR结果显示，Nur77能够正调控瘦素leptin下游厌食多肽POMC的表达。脑室内注射leptin，能够显著抑制野生型小鼠的食欲，并促进脂肪和肝脏组织中脂质氧化，减少脂质合成，从而大幅降低体...Orphan nuclear receptor Nur77 (also called TR3) is a member of the nuclear hormone receptor 4A (NR4A) subgroup and emerged as an important regulator of metabolism in liver, adipose tissue and skeletal muscle. Therefore it is considered as a novel therapeutic target for metabolic diseases. In this study, we found that under normal physiological conditions, the body weight of Nur77 knockout mice was...学位：理学硕士院系专业：生命科学学院_细胞生物学学号：2162012115243