Development of an Enzyme-Linked Immunosorbent Spot Assayto Measure Serum Neutralizing Antibodies against Type I Herpes Simplex Virus

单纯疱疹病毒（HerpesSimplexVirus，HSV）属于疱疹病毒科a病毒亚科，根据血清型和抗原性的差异，单纯疱疹病毒分为I型和II型（HSV-1、HSV-2）。其中HSV-1病毒主要引起口唇性疱疹，HSV-2病毒主要引起生殖器疱疹。HSV-1病毒相比于HSV-2病毒危害性较小，80%以上的中国人都曾经感染过HSV-1病毒。 恶性肿瘤严重威胁着人类生命健康，其发生率呈逐年上升趋势。据世界卫生组织2010年统计结果显示目前肿瘤引起的死亡数目已经超越心脑血管疾病引起的死亡数目而跃居首位。随着肿瘤诊疗技术水平的不断提高，早期肿瘤患者的整体生存率显著提高，但是中晚期肿瘤患者生存率仍相对较低。目...Herpessimplexvirus (HSV), also as known as human herpesvirus, belongs to the Herpesviridae family, alphaherpesvirinae subfamily. According to the serotype and antigenicity,herpes simplex virus is divided into two types: type I and II herpes simplex virus (HSV-1 and HSV-2). HSV-1 causes primarily oral infections while HSV-2 more commonly causes genital infections. HSV-2 infection causes more severe...学位：理学硕士院系专业：生命科学学院_细胞生物学学号：2162012115241