Relationship between abnormal symptoms of Prader-Willi syndrome model --Snord116 deletion mice and Ghrelin signaling pathway

Prader–Willi综合症是以进食异常和血液Ghrelin异常升高为特征的遗传肥胖症。其病因是Snord116SnoRNA群的表达缺失。我们构建的Snord116del小鼠模型表现出贪食和血液Ghrelin升高等PWS症状。此次研究中，我们繁育野生型（WT）、Snord116del（SW）、Ghrl-/-（WG）、Ghsr-/-（WR）小鼠，并制备[Snord116del，Ghrl-/-]（SG）和[Snord116del，Ghsr-/-]（SR）双敲除小鼠，对其生长发育、进食和血液Ghrelin水平进行研究，以此探究Ghrelin信号通路是否为维持PWS症状所必需。通过监测WT、SW、W...Prader-Willi syndrome is a genetic obesity disease characterized by eating abnormality and hyperGhrelinemia. A deletion of Snord116 snoRNA cluster has been identified as the major contributor. The Snord116del mouse model we created manifested PWS symptoms including hyperphagia and hyperghrelinemia. In this study, we breeded wildtype (WT), Snord116del (SW), Ghrl-/-(WG), Ghsr-/-(WR), generated [Snor...学位：理学硕士院系专业：生命科学学院_生物化学与分子生物学学号：2162013115257