Mechanism of Mst1/2 kinases regulating PKCα-mediated the activation of Rac1

当病原细菌入侵机体时，吞噬细胞（如巨噬细胞和嗜中性粒细胞等）会通过吞噬泡吞噬细菌；这一过程还伴随着线粒体以及NADPH氧化酶向吞噬泡募集并释放大量的ROS，来杀伤和清除病原细菌；其中，结合GTP的激活形式的RhoGTP酶蛋白家族成员Rac1和Rac2对于NADPH氧化酶激活的细胞吞噬过程是必需的。本实验室已有研究表明，在髓系细胞（单核细胞、巨噬细胞和嗜中性粒细胞等）条件性双敲除Mst1和Mst2的小鼠（Mst1fl/flMst2fl/flLyz2-Cre，cDKO）中，与野生型小鼠相比，对外来病原体入侵更易感、表现为血清中炎症因子大量增加、对病原体吞噬和清除能力下降、小鼠存活率显著降低等一系列...Phagocytes (such as macrophage and neutrophil )are specialized cells of the immune system that engulf harmful microorganisms and destroy them in phagosomes. This process is accompanied with the juxtapostion of mitochondria to phagosomes and the production of large amounts of reactive oxygen species (ROS). Moreover,the‘GTP-charged’active form of the Rho-family GTPases Rac1 and Rac2 is required for ...学位：理学硕士院系专业：生命科学学院_生物化学与分子生物学学号：2162013115262