The role of EGFR/ERK signaling for the self-renewal of germinative cells of Echinococcus multilocularis and its molecular mechanism

多房棘球绦虫（Echinococcusmultilocularis，Em）中绦期幼虫(泡球蚴)在人体内以类似肿瘤的方式进行不断的增殖发育，引发严重的人兽共患泡球蚴病（Alveolarechinococcosis，AE）。泡球蚴不断增殖发育的基础是其生发细胞的自我更新和分化能力，这一特性类似于干细胞。表皮生长因子受体（EGFR）介导的EGFR/ERK信号通路是调控各种干细胞自我更新的主要通路之一，在进化上具有高度的保守性。 本文利用RealtimePCR、WesternBlot、免疫组化荧光和EdU-BrdU双染等技术，从以下三个方面探讨了EGFR/ERK信号通路在泡球蚴生发细胞自我更新中的作...Echinococcus multilocular larvae, which spread to organ surfaces in vivo in a tumor-like way, could cause alveolar echinococcosis, a dangerous zoonotic parasitic diseases. The growth and development of Echinococcus multilocular larvae are based on germinative cells which have strong capacities of self-renewal and differentiation. EGFR/ERK signal pathway is one of the most important signals in regu...学位：理学硕士院系专业：生命科学学院_动物学学号：2162013115247