Generation and Characterization of HCMV Specific Human Antibody to Explore Antibody Response Profile in HCMV Naturally Infected Individuals

人巨细胞病毒（Humancytomegalovirus，HCMV）是一种常见的疱疹病毒，在人群中普遍感染，儿童感染率约为10%-40%，成人为50%-90%，大部分感染者为无临床症状的健康人。但机体免疫功能低下的人群如器官移植患者及AIDS病人，更易发生HCMV病毒的新发或复发感染，引起致命疾病如肺炎、肝炎、脑炎等，从而导致器官移植失败及术后死亡；同时HCMV病毒也是宫内感染中危害最大的病毒之一，感染率占怀孕妇女的0.5%-2%，尤其是在发展中国家较为常见，孕妇感染后自身多无明显症状或轻微症状，但是病原体可以通过胎盘传染给胎儿，引起死胎、早产、流产或胎儿先天性神经管缺陷，因此HCMV的预防及治...Human cytomegalovirus (HCMV) is one of the most common and challenging herpesvirusesin the world, it infects a large proportion of the human population (50-90% among adults and 10-40% among children) including immunocompromised patients especially for transplant recipients with immune suppression, causes severe diseases such as pneumonia, hepatitis, encephalitis and remains a risk factor for trans...学位：理学博士院系专业：生命科学学院_生物化学与分子生物学学号：2162010015389