The molecular mechanism of receptor UNC5C regulated adhesion invasion and migration of breast cancer

神经导向分子最初因在神经系统发育中具有重要作用而被广泛研究，近年来的研究发现，其在血管新生和肿瘤发展等方面也发挥着重要的调控作用。Netrin-1的受体主要包括UNC5和DCC两大家族，其中UNC5B是首个被证实参与血管发育调控的UNC5家族成员，DCC是早在1990年被发现并命名的重要抑癌基因。许多研究证实，神经导向分子Netrin及其受体参与肿瘤发生发展，其中在细胞的存活，凋亡，侵袭迁移和肿瘤血管新生等方面均有重要作用，但相关分子机制的研究还少见报道。本实验室前期研究发现，通过干扰和过表达实验技术，证实在乳腺癌细胞中敲减UNC5C能够促进乳腺瘤细胞在体内和体外增殖、迁移和侵袭，在MDA-M...Axon guidance molecules (AGM) systems due to play an important role in the development of nervous system and has been widely studied, previous studies found that they are also play an important role in the aspect of angiogenesis and tumor development . Netrin-1 receptor mainly includes UNC5 and DCC two families, of which UNC5B is the first proved to be involved in the regulation of vascular grow...学位：理学硕士院系专业：生命科学学院_生物化学与分子生物学学号：2162012115235