The role of Itch-mediated PPARγ ubiquitination in adipocyte differentiation

脂质过氧化物酶体增殖物激活受体γ（PPARγ）属于Ⅱ型核受体超家族成员，在脂肪及小肠组织中高表达。作为重要的核转录因子，PPARγ与视黄醇类X受体α(retinoidXreceptorα)形成异二聚体，随后结合在过氧化物酶体增殖物反应元件(PPRE)上，从而调控与脂肪分化、脂质代谢、炎症应答相关的靶基因表达，其功能的异常与糖尿病、肥胖等代谢疾病密切相关。临床上，PPARγ也被作为重要的药物靶点用于相关疾病的治疗。 PPARγ的翻译后修饰对其生物学功能有重要影响。我们发现C2-WW-HECTE3泛素连接酶家族成员Itch可以和PPARγ相互结合并对其进行非典型泛素化修饰。这种非典型的泛素化修饰...The peroxisome proliferator-activated receptor gamma (PPARγ) belongs to typeⅡnuclear receptor superfamily, which is highly expressed in adipose tissue and intestine. As a crucial transcriptional factor, PPARγ forms a heterodimer with retinoid X receptor α and subsequently binds to PPAR-responsive regulatory elements to regulate its target genes which involved in adipogenesis, lipid metabolism, inf...学位：理学硕士院系专业：生命科学学院_细胞生物学学号：2162013115253