Preliminary chemical investigation of NSF—Characterization and structure analyses of the substituted products of phosphate and phosphite with gadolinium aminopolycarboxylates

以钆离子为中心的多氨多羧酸螯合物由于其独特的电子结构和磁学性能被广泛应用于核磁共振成像(MagneticResonanceImaging,MRI)中作为造影剂。自1984年首次应用造影剂二乙三胺五乙酸钆（Gd-DTPA）进行脑肿瘤的增强显像研究以来，人们对钆基造影剂进行大量的研发和临床研究。通常，钆基造影剂都具有很高的热力学稳定性和动力学惰性以保证安全，然而研究表明，对于一些肾功能障碍的患者，钆基造影剂注射入体内后可能会与体内的可溶性无机磷酸盐、金属离子和其它成分发生复杂的反应最终生成磷酸钆复合生物微粒，进而引起一种危险的疾病：肾源性系统纤维化。因此，对于钆基螯合物造影剂与磷酸类无机小分子的反...Gadolinium polyaminocarboxylates were widely used in Magnetic Resonance Imaging as contrast agents due to their unique electron structure and magnetic properties. Since the first gadolinium based contrast agent (GBCA) Gd-DTPA was clinical used in 1984, the GBCAs have been broadly investigated and clinically tested. Generally, the Gd3+ was coordinated by the chelating ligand to obtain thermodynamic...学位：工学博士院系专业：化学化工学院_工业催化学号：2062012015346