Production of 1,3-Propanediol from Raw Glycerol by Biocatalytic Transformation

1，3-丙二醇（1，3-PD）是一种重要的化工原料，具有广泛的应用领域。发酵法生产1，3-PD以利用可再生资源等优点日益受到重视。大部分研究以纯甘油为底物，成本高，如果以粗甘油为底物，可大大降低生产成本。 本论文的研究目的是以粗甘油为底物，以Clostridiumbutyricum（丁酸梭状芽孢杆菌）为生产菌株，通过厌氧发酵生产1，3-PD，在粗甘油预处理、提高菌体浓度、提高单位菌体生产能力、延长发酵周期和建立动力学模型这几个方面进行了研究，主要结果如下： （1）分批发酵结果表明粗甘油对发酵有明显的抑制作用。用粉状活性炭对粗甘油进行吸附预处理可显著降低抑制作用。通过均匀设计对预处理条件进行...1,3-Propanediol (1,3-PD) is an important chemicals with wide range of applications. Microbial production of 1,3-PD has attracted wide attentions in that it uses renewable resources. Most studies were done using pure glycerol and its cost was high. The cost could be reduced if raw glycerol is used. In this paper, raw glycerol was used for 1,3-PD fermentation by Clostridium butyricum under anaerobi...学位：工学博士院系专业：化学化工学院_工业催化学号：2062009015329