Philadelphia-like B-cell precursor acute lymphoblastic leukemia (Ph-like ALL) is characterized by distinct genetic alterations and inferior prognosis in children and younger adults. The purpose of this study was a genetic and clinical characterization of Ph-like ALL in adults. Twenty-six (13%) of 207 adult patients (median age: 42 years) with B-cell precursor ALL (BCP-ALL) were classified as having Ph-like ALL using gene expression profiling. The frequency of Ph-like ALL was 27% among 95 BCP-ALL patients negative for BCR-ABL1 and KMT2A-rearrangements. IGH-CRLF2 rearrangements (6/16; P=0.002) and mutations in JAK2 (7/16; P<0.001) were found exclusively in the Ph-like ALL subgroup. Clinical and outcome analyses were restricted to patients tre...
Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL) is the most common subtype o...
International audienceThe outcome of adult patients with Philadelphia chromosome-negative acute lymp...
The outcome for adults and children with Philadelphia chromosome acute lymphoblastic leukemia (ALL) ...
Philadelphia-like B-cell precursor acute lymphoblastic leukemia (Ph-like ALL) is characterized by di...
Philadelphia-like B-cell precursor acute lymphoblastic leukemia (Ph-like ALL) is characterized by di...
Purpose: Philadelphia chromosome (Ph) -like acute lymphoblastic leukemia (ALL) is a high-risk subtyp...
Purpose Philadelphia chromosome (Ph) -like acute lymphoblastic leukemia (ALL) is a high-risk subtyp...
Early recognition of Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) cases could impa...
Multiple cytogenetic subgroups have been described in adult Philadelphia chromosome (Ph)-negative B-...
Multiple cytogenetic subgroups have been described in adult Philadelphia chromosome (Ph)-negative B-...
Multiple cytogenetic subgroups have been described in adult Philadelphia chromosome (Ph)-negative B-...
With intensified pediatric-like therapy and genetic disease dissection, the field of adult acute lym...
BACKGROUND: Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized...
In contrast to acute lymphoblastic leukemia in children, adult cases of this disease are associated ...
none27siIntroduction High-resolution genome-wide profiling analysis of B-cell precursor acute lympho...
Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL) is the most common subtype o...
International audienceThe outcome of adult patients with Philadelphia chromosome-negative acute lymp...
The outcome for adults and children with Philadelphia chromosome acute lymphoblastic leukemia (ALL) ...
Philadelphia-like B-cell precursor acute lymphoblastic leukemia (Ph-like ALL) is characterized by di...
Philadelphia-like B-cell precursor acute lymphoblastic leukemia (Ph-like ALL) is characterized by di...
Purpose: Philadelphia chromosome (Ph) -like acute lymphoblastic leukemia (ALL) is a high-risk subtyp...
Purpose Philadelphia chromosome (Ph) -like acute lymphoblastic leukemia (ALL) is a high-risk subtyp...
Early recognition of Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) cases could impa...
Multiple cytogenetic subgroups have been described in adult Philadelphia chromosome (Ph)-negative B-...
Multiple cytogenetic subgroups have been described in adult Philadelphia chromosome (Ph)-negative B-...
Multiple cytogenetic subgroups have been described in adult Philadelphia chromosome (Ph)-negative B-...
With intensified pediatric-like therapy and genetic disease dissection, the field of adult acute lym...
BACKGROUND: Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized...
In contrast to acute lymphoblastic leukemia in children, adult cases of this disease are associated ...
none27siIntroduction High-resolution genome-wide profiling analysis of B-cell precursor acute lympho...
Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL) is the most common subtype o...
International audienceThe outcome of adult patients with Philadelphia chromosome-negative acute lymp...
The outcome for adults and children with Philadelphia chromosome acute lymphoblastic leukemia (ALL) ...