Thrombotic thrombocytopenic purpura
- Kremer Hovinga, Johanna A
- Coppo, Paul
- Lämmle, Bernhard
- Moake, Joel L
- Miyata, Toshiyuki
- Vanhoorelbeke, Karen
DOIAbstract
Thrombotic thrombocytopenic purpura (TTP; also known as Moschcowitz disease) is characterized by the concomitant occurrence of often severe thrombocytopenia, microangiopathic haemolytic anaemia and a variable degree of ischaemic organ damage, particularly affecting the brain, heart and kidneys. Acute TTP was almost universally fatal until the introduction of plasma therapy, which improved survival from <10% to 80-90%. However, patients who survive an acute episode are at high risk of relapse and of long-term morbidity. A timely diagnosis is vital but challenging, as TTP shares symptoms and clinical presentation with numerous conditions, including, for example, haemolytic uraemic syndrome and other thrombotic microangiopathies. The underlyin...
Add to ORKG