Statistical methods for extracting information from the raw accelerometry data and their applications in public health research

Indiana University-Purdue University Indianapolis (IUPUI)Various methods exist to measure physical activity (PA). Subjective methods, such as diaries and surveys are relatively inexpensive ways of measuring one’s PA; how ever, they are riddled with measurement error and bias due to self-report. Wearable accelerometers offer a noninvasive and objective measure of subjects’ PA and are now widely used in observational and clinical studies. Accelerometers record high frequency data and produce an unlabeled time series at the sub-second level. An important activity to identify from such data is walking, since it is often the only form of exercise for certain populations. While much work has been done to advance the use of accelerometers in public health research, methodology is needed for quan tifying the physical characteristics of different types of PA from the raw signal. In my dissertation, I advance the accelerometry research methodology in a three-paper sequence. The first paper is a novel application of functional linear models to model the physical characteristics of walking. We emphasize the signal processing used to prepare the data for analyses, and we apply the methods to a motivating dataset collected in an elder population. The second paper addresses the classification of PA. We designed an experiment and collected the data with the purpose of extracting useful and interpretable features for differentiating among walking, descending stairs, and ascending stairs. We build subject-specific classification models utilizing a tree based classifier. We evaluate the effects of sensor location and tuning parameters on the classification rate of these models. The third paper addresses the classification of walking types at the population level. We propose a robust normalization of features extracted for each subject and compare the model classification results to evaluate the effect of feature normalization. In summary, this work provides a framework for better use of accelerometers in the study of physical activity.2 year