Melatonin and Nitrones As Potential Therapeutic Agents for Stroke

Stroke is a disease of aging affecting millions of people worldwide, and recombinant tissue-type plasminogen activator (r-tPA) is the only treatment approved. However, r-tPA has a low therapeutic window and secondary effects which limit its beneficial outcome, urging thus the search for new more efficient therapies. Among them, neuroprotection based on melatonin or nitrones, as free radical traps, have arisen as drug candidates due to their strong antioxidant power. In this Perspective article, an update on the specific results of the melatonin and several new nitrones are presented.JM-C is indebted to Ministerio de Economía y Competitividad (es) (MINECO) for grants SAF2012-33304, and SAF2015-65586-R. FL-M, MJO-G and JM-C thank Universidad Camilo José Cela (Project 2015-12 (NITROSTROKE)) for continued support.Peer reviewedPeer Reviewe